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KMID : 0359920100290060761
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Korean Journal of Nephrology
2010 Volume.29 No. 6 p.761 ~ p.767
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Risk Factors for New Onset Diabetes after Transplantation among Renal Transplant Recipients Treated with Tacrolimus
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Choi Yu-Kyong
Kim Ye-Jee
Choi Nam-Kyong
Kim Min-Young
Baek Na-Na
Youm Ji-Youn
Lee Jung-Eun
Kim Dae-Joong
Kim Yoon-Goo
Oh Ha-Young
Huh Woo-Sung
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Abstract
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Purpose: This study was conducted to identify risk factors for new onset diabetes after transplantation (NODAT) among renal transplant recipients treated with tacrolimus-based immunosuppressant.
Methods: We selected renal transplant recipients who underwent surgery at Samsung Seoul Hospital between May 2001 and July 2009. Exclusion criteria were as follows: recipients <18 years old, history of diabetes mellitus (DM) or impaired glucose tolerance. Analysis of possible risk factors for NODAT included age, gender, body mass index, co-morbid diseases, family history of DM, infection of hepatitis B or polyomavirus, type of donors (cadaver or living) and acute rejection. Overall incidence and median value of NODAT onset day were analyzed with Kaplan-Meier curve. We calculated crude incidence rate and relative risk (RR) and 95% confidence interval (CI) for independent risk factors of NODAT using Cox proportional hazard analysis.
Results: A total of 278 patients were included and the incidence of NODAT was 13.3% (5.6/100 person-year) and the median duration of NODAT onset was 28 days. In Cox analysis, risk factors for NODAT were age (45-59 years: RR=1.41, 95% CI 1.09-1.83, 60> years: RR=4.36, 95% CI 2.00-9.49), family history of DM (RR=1.62, 95% CI 1.12-2.34) and polyomavirus infection (RR=1.40, 95% CI 1.08-1.81).
Conclusion: The risk factors for NODAT among renal transplant recipients treated with tacrolimusbased regimen were age (>45 years old), family history of DM and polyomavirus infection.
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KEYWORD
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Kidney transplantation, Diabetes mellitus, Tacrolimus
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